Clinical Trials

The University of Chicago Medicine has on-going clinical trials and research objectives. Details about our different trials can be found below.

Treatment of Prostate Cancer

TULSA-PRO MRI-Guided Transurethral Ultrasound Prostate Ablation Device in Patients with Localized Prostate Cancer: a Prospective, Single-Arm, Pivotal Clinical Study

Funded by Profound Medical.

Please click the image of our pamphlet below for detailed information regarding this study. Study no longer open for new patient enrollment. 

Diagnosis with Prostate MRI

Quantitative DCEMRI of Prostate Cancer – Correlation with Gold Standards

Funded by a National Institute of Health (NIH) grant

Dynamic contrast enhanced imaging (DCEMRI) has the potential to provide critical information to guide therapy and improve outcomes for prostate cancer patients. The purpose of this research study is to improve the diagnosis and management of patients with prostate cancer by developing standardized methods for DCEMRI, testing its variability and accuracy, and determining if it can improve discrimination between high and low Gleason grade cancers.

Only existing University of Chicago patients referred to us by the Urology Department are enrolled in this trial.

Development of Advanced Magnetic Resonance Imaging Sequences for Improved Quantitative Diagnosis of Thoracic-Abdominal-Pelvic Diseases

The purpose of this study is to develop an improved, state of the art, Magnetic Resonance Imaging (MRI) method for evaluating diseases of the thorax, abdomen and pelvis, including the prostate region. This research is being done to better understand the methods used for MRI, and to enable clinicians to use MR imaging technologies to their fullest capabilities.

Only existing University of Chicago patients are enrolled in this trial.

MRI Derived Quantitative Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

The purpose of this study is to test and validate an artificial intelligence-based Risk Map DSS tool developed by our research group. This is a Decision Support System (DSS) image analysis software for automated interpretation of prostate MR. This tool can potentially identify additional areas of clinically significant cancer in the prostate that may have otherwise been missed by standard TRUS-guided biopsy. Our goal is to use this advanced and innovative technology for accurate and reliable prostate cancer diagnosis, and to provide patients and treating physicians with data that will enable them to make informed treatment decisions.

Only existing University of Chicago patients referred to us by the Urology Department are enrolled in this trial.

Computer-Aided Diagnosis

Computer-Aided Diagnosis of Prostate Cancer with Multiple-parametric MR Imaging

Funded by a Department of Defense grant
The purpose of this research study is to develop a database of multi-parametric MR images with corresponding histopathology, assess the correlation among MRI image features and histopathological characteristics of the tumor and normal regions of the prostate, and finally the pilot development of a computer-aided diagnosis (CAD) system to identify suspicious regions in MR images of the prostate.

This is a retrospective review of existing patients; we are not enrolling for this clinical trial.

Sanford J. Grossman Center

Dr. Aytekin Oto has received a $ 1,000,000 gift from the Sanford J. Grossman Charitable Trust. This gift will be used to fund the Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy.

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